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Sanofi and Regeneron Pharmaceuticals Inc have expanded a clinical trial of their rheumatoid arthritis drug Kevzara as a coronavirus treatment to patients outside the United States. 

The companies said enrolments for the mid-to-late stage trial of Kevzara, an immune-system modifying drug known as a monoclonal antibody, have now started in Italy, Spain, Germany, France, Canada, and Russia. 

The trial, expected to enroll about 300 patients, will recruit hospitalized patients from several countries who are severely or critically ill with COVID-19 infection, a disease caused by the highly contagious coronavirus. 

Italy and Spain have been two of the worst-hit countries in Europe, recording the highest and the second highest death toll from coronavirus of any country in the world, respectively. 

Doctors have seen that many of those who become critically ill from SARS-CoV2 are experiencing a so-called cytokine storm, which happens when the immune system overreacts and attacks the body’s organs. 

(Source: CNBC, 2020)