Drug Dissolution Kinetics

Drug dissolution kinetics characterises solid pharmaceutical breakdown into solution enabling absorption. Noyes-Whitney equation mathematically describes dissolution rate. Surface area expansion through particle size reduction increases dissolution. pH effects reflect solubility dependence. Polymorphic form differences substantially influence dissolution rates.

Stress testing establishes representative dissolution behaviour. Medium selection reflects intended administration site. Bioavailability correlation demonstrates dissolution-absorption relationship. Regulatory specifications establish dissolution criteria. Post-approval monitoring confirms consistency.