Dynamic Light Scattering Analysis

Dynamic light scattering analysis characterises particle and macromolecule size distributions employing laser-induced intensity fluctuations. Hydrodynamic radius determination from scattering correlation functions provides average particle size. Polydispersity assessment detects heterogeneous size distributions indicating formulation quality concerns. Temperature-dependent measurements characterise thermal stability.

Biopharmaceutical applications include therapeutic protein aggregation monitoring during storage. Nanoparticle size characterisation supports quality control assessment. Particle size changes indicating formulation destabilisation trigger investigation. Regulatory specifications establish acceptable size distribution ranges. Emerging nanoparticle tracking analysis provides individual particle counting complementing ensemble measurements.