Extravascular Fluid Accumulation

Extravascular fluid accumulation describes drug leakage into tissue spaces potentially causing local toxicity. Vesicant chemotherapy agents cause tissue necrosis from extravasation. Prevention through central lines reduces extravasation risk. Early detection through pain and swelling enables prompt management. Treatment approaches including cooling and antidote administration minimise tissue damage.

Infusion site monitoring by trained personnel detects extravasation. Patient education emphasises symptom reporting. Regulatory labelling incorporates extravasation information. Clinical protocols establish management procedures. Emerging technologies including infrared imaging enable earlier detection.