Eye Irritation Potential

Eye irritation potential characterises pharmaceutical substances and formulations causing reversible conjunctival inflammation without corneal damage. In vitro eye irritation models using reconstructed corneal tissues provide non-animal alternatives. Rabbit eye irritation remains regulatory standard for ophthalmic products. Draize scoring quantitates inflammation severity. Recovery assessment within 7-21 days distinguishes irritation from corrosion.

Ophthalmic formulation development optimises safety reducing irritation. pH buffering and osmolality adjustment minimise physical irritation. Preservative selection balances antimicrobial efficacy against irritation potential. Regulatory labelling emphasises irritation warnings. Patient populations with sensitive eyes require particular attention.