Fusion Protein Engineering

Fusion protein engineering combines multiple protein domains creating multifunctional therapeutics. Antibody-enzyme fusion proteins generate catalytic antibodies. Cytokine receptor fusion proteins antagonise inflammatory signalling. Toxin-antibody fusion proteins deliver cytotoxins to target cells. Domain spacing and orientation optimise fusion protein function.

Production systems require expression optimisation for complex fusion proteins. Formulation challenges address fusion protein instability. Immunogenicity assessment accounts for non-natural protein architecture. Regulatory submissions justify fusion protein utility. Clinical translation requires comprehensive characterisation.