In Vivo Imaging

In Vivo Imaging encompasses non-invasive visualisation technologies enabling real-time or longitudinal observation of biological processes, anatomical structures, or therapeutic effects within living organisms. These diverse modalities include optical imaging, positron emission tomography, magnetic resonance imaging, ultrasound, and computed tomography. Imaging capabilities span molecular events through whole-organism physiology.

The biopharmaceutical industry employs in vivo imaging across preclinical research, development, and clinical applications. Preclinical efficacy studies use imaging monitoring tumour growth or treatment responses, reducing animal numbers through longitudinal designs. Biodistribution studies employ labelled compounds tracking drug delivery to target tissues. Target engagement imaging confirms drug-target interactions in living systems. Clinical development incorporates imaging for patient selection, pharmacodynamic assessments, response evaluation, and safety monitoring. Theranostic approaches combine therapeutic and diagnostic imaging enabling personalised treatment monitoring. As molecular imaging advances and artificial intelligence improves image analysis, in vivo imaging increasingly contributes mechanistic insights and clinical care through non-invasive visualisation.