Jejunal Transporter Expression

Jejunal transporter expression determines intestinal drug absorption via active transport mechanisms. PEPT1 transporter actively absorbs peptides and peptidomimetics. OATP transporters mediate organic anion transport. Substrate-specific transport enables absorption of otherwise poorly-permeable drugs. Genetic variations in transporter expression explain interindividual bioavailability differences.

Bioavailability assessment accounts for transporter involvement. Formulation strategies compensate for transporter saturation. Drug-drug interactions via transporter competition alter absorption. Regulatory submissions address transporter-mediated absorption. Post-approval monitoring confirms absorption predictions.