Liver Microsomal Metabolism

Liver microsomal metabolism characterises hepatic enzyme-catalysed drug biotransformation employing isolated subcellular fractions. Microsomes contain cytochrome P450 and phase II enzymes. Substrate specificity identifies metabolising enzyme involvement. Inhibitor and inducer screening predicts drug-drug interactions. Metabolism rate quantitation guides clearance predictions.

Human versus animal metabolism assessment informs translation. Metabolite characterisation supports metabolite-related toxicity assessment. Regulatory submissions include microsomal metabolism data. Pharmacokinetic predictions guide dose selection. Post-approval monitoring confirms predicted metabolism.