Lymphocyte Transformation Test

Lymphocyte transformation test detects T-cell sensitisation to drug compounds predicting allergic potential. Lymphocyte proliferation indicates immune recognition. Flow cytometry quantitates activated cell populations. Interferon-gamma release indicates Th1 activation. Predictive value varies by drug class and mechanism.

Sensitivity and specificity assessment establishes test utility. Regulatory acceptance supports drug allergy prediction. Patient testing identifies at-risk populations. Post-approval monitoring detects unexpected sensitisation patterns. Emerging immunological assays improve predictive accuracy.