Lymphocyte transformation test detects T-cell sensitisation to drug compounds predicting allergic potential. Lymphocyte proliferation indicates immune recognition. Flow cytometry quantitates activated cell populations. Interferon-gamma release indicates Th1 activation. Predictive value varies by drug class and mechanism.
Sensitivity and specificity assessment establishes test utility. Regulatory acceptance supports drug allergy prediction. Patient testing identifies at-risk populations. Post-approval monitoring detects unexpected sensitisation patterns. Emerging immunological assays improve predictive accuracy.
General Biopharmaceutical Concepts
Lymphocyte Transformation Test
The lymphocyte transformation test measures lymphocyte proliferation following antigen exposure to assess cellular immune responses or drug hypersensitivity.
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