Membrane Transporter Expression

Membrane transporter expression determines drug absorption and excretion via active mechanisms. P-glycoprotein-mediated efflux impairs bioavailability. Organic anion transporters actively absorb drugs. Genetic polymorphisms explain interindividual transporter variation. Developmental expression changes influence paediatric pharmacokinetics.

Bioavailability assessment accounts for transporter involvement. Formulation strategies compensate for transporter saturation. Drug-drug interactions via transporter competition alter absorption. Regulatory submissions address transporter-mediated pharmacokinetics. Post-approval monitoring confirms transporter predictions.