Quaternary structure characterisation determines multi-subunit protein assembly affecting therapeutic potency. Native mass spectrometry preserves quaternary structure enabling analysis. Size exclusion chromatography measures oligomeric state. Cross-linking studies identify inter-subunit contacts. Conformational dynamics affect functional assembly.
Regulatory submissions include quaternary structure documentation. Aggregate formation indicates structural instability. Post-approval monitoring confirms structure maintenance. Emerging cryo-EM reveals atomic quaternary details. Manufacturing consistency ensures proper assembly.
Cell & Gene Therapy
Quaternary Structure Characterisation
Quaternary structure characterisation analyses the arrangement and interactions of multiple protein subunits to confirm structural integrity and biological function.
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